Medical Ozone - introduction

Regenerative Medicine

Regenerative medicine, sometimes called restorative medicine, is an evolving field that focuses on repairing and rebuilding the body’s own tissues. Its growing popularity is supported not only by clinical evidence but also by the fact that many high-profile individuals have turned to these treatments. Cristiano Ronaldo used ozone therapy to recover from a knee injury, while Madonna has spoken openly about using autohemotherapy with ozone to maintain her energy and vitality on tour. Even Queen Elizabeth The Queen Mother was reported to have used ozone-based injections to preserve her health and longevity.

Although often described as cutting-edge, regenerative therapies have been practised safely for decades. These treatments work by stimulating the body’s natural repair mechanisms — improving circulation, reducing inflammation, and encouraging the healing of damaged tissue. Today, regenerative approaches such as Prolozone and autohemotherapy are valuable tools in the treatment of tendon, ligament, and joint problems, as well as in supporting overall health and recovery.

Phases of Tissue Repair

The Role of Oxygen in Healing

Oxygen is fundamental to life. Beyond the simple act of breathing, our cells rely on oxygen for energy, repair, and healthy function. Without adequate oxygen at the cellular level, the body cannot repair itself effectively, leading to discomfort, pain, and reduced mobility.

Injury, trauma, and age-related degeneration can restrict oxygen delivery to tissues, resulting in inflammation, spasm, and impaired healing. Ozone Therapy directly addresses this problem by improving blood flow to damaged tissues. With greater circulation comes improved oxygenation, hydration, and nutrition — creating the conditions needed for healing and regeneration.

Detailed Phases of Tissue Repair

What is Ozone Therapy?

Ozone therapy is a medical treatment that uses a highly active form of oxygen (O₃) to stimulate biological repair, control infection, and restore physiological balance. Unlike the oxygen we breathe (O₂), ozone contains an additional oxygen atom, which gives it unique oxidative and signalling properties. When administered in controlled medical doses, ozone acts as a powerful biological modulator — enhancing the body’s ability to heal and regulate itself.

The therapeutic potential of ozone has been recognised for more than 125 years. It has been applied in hospitals and clinics across Europe, the Americas, and Asia in the treatment of a wide spectrum of conditions. Far from being experimental, ozone therapy has a long-established safety record when delivered by trained practitioners.

Cristiano Ronaldo,

Madonna and

the late Queen Mother

have turned to

ozone therapy

for recovery,vitality

and longevity.

Documented Clinical Effects Include:

Enhanced oxygen delivery and circulation – optimising how red blood cells release oxygen and how tissues utilise it.
Immune system regulation – balancing immune over-activity in autoimmune conditions while supporting immune defence in chronic infections.
Potent antimicrobial activity – directly inactivating bacteria, viruses, fungi, and parasites.
Anti-inflammatory effects – reducing oxidative stress, lowering inflammatory mediators, and alleviating pain.

Tissue repair and regeneration – stimulating growth factors, collagen synthesis, and stem cell activity to support long-term healing.

Formation of Ozone

How Does it Work?

The therapeutic effects of ozone are mediated through its interaction with biological fluids. When ozone contacts blood, joint fluid, or other tissues, it reacts almost instantly to form a range of short-lived but highly active molecules known as ozonides. These ozonides function as biochemical messengers, initiating a cascade of adaptive responses that enhance cellular resilience and repair.

Key mechanisms of action include:

Improved oxygen utilisation – Ozone enhances the ability of red blood cells to release oxygen into tissues and stimulates mitochondrial function, resulting in more efficient energy (ATP) production.
Immune modulation – Ozone “resets” immune function, activating it in cases of chronic infection and down-regulating excessive activity in autoimmune disorders.
Antimicrobial effect – The oxidative action of ozone rapidly inactivates pathogens, including resistant bacteria, viruses, fungi, and parasites, without harming healthy human cells.
Anti-inflammatory response – By reducing oxidative stress and improving microcirculation, ozone therapy decreases pro-inflammatory cytokines and relieves pain associated with chronic inflammation.
Regenerative signalling – Ozone stimulates the release of growth factors, enhances antioxidant enzyme production, and promotes stem cell activity, supporting structural repair of joints, ligaments, and connective tissue.

Ozone Therapy Timeline

Combining Ozone with Advanced Physiotherapy

Ozone therapy is a medical treatment that introduces a highly active form of oxygen (O₃) into the body to stimulate repair, reduce pain, and restore cellular balance. For musculoskeletal (MSK) conditions such as osteoarthritis, tendon and ligament injuries, or chronic back and neck pain, ozone improves tissue oxygenation, reduces inflammation, and accelerates natural healing responses.

When combined with advanced physiotherapy techniques — such as manual therapy, neuromuscular re-education, and progressive rehabilitation — ozone therapy enhances outcomes by addressing both the structural and cellular drivers of MSK dysfunction. While physiotherapy restores mobility, strength, and biomechanical alignment, ozone works at the biochemical level to improve circulation, reduce oxidative stress, and promote regeneration of cartilage, ligaments, and connective tissue.

Our integrated approach often helps patients regain mobility and reduce pain to a degree that surgery can be postponed or avoided altogether. By combining advanced physiotherapy with regenerative ozone, we aim to maximise recovery potential before surgical intervention is considered.

The dual approach of ozone therapy with advanced MSK physiotherapy therefore provides a comprehensive strategy:

Pain relief through reduced inflammation and improved joint mechanics
Accelerated recovery by enhancing tissue healing and repair
Improved function through restoration of stability, mobility, and muscle balance
Long-term benefit by addressing both symptom relief and underlying tissue health

Ozone therapy has been used safely in medicine for over 125 years and is now practised worldwide. At Physio Barnsley, it forms part of an integrated approach to MSK care, helping patients recover more fully and return to movement with confidence.

ProlozoneWHAT TO EXPECT

IV Ozone WHAT TO EXPECT

Ozone Molecule

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Physio Barnsley was founded in 2004 by Peter Hartley. Together the clinical team provide revolutionary treatments unlike any other physiotherapy clinic in the UK.