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MEDICAL OZONE INJECTIONS IN BARNSLEY

Prolozone: ozone injections for joints, muscles & ligaments

A targeted injection of medical-grade oxygen-ozone, given by our certified medical ozone clinicians and combined with hands-on rehab. Backed by controlled clinical trials for back pain, knee osteoarthritis, shoulder and heel pain.

Over 1400 Active Clients

Close-up of medical ozone being delivered into damaged tendon tissue near a joint during prolozone therapy
Complimentary 30 minute callFind out if ozone suits you

What the research shows

Ozone injections have been tested in randomised controlled trials, including against dummy treatments and against steroid injections. Here's what they found.

61%

of patients with disc-related back pain were pain-free six months after ozone injections, compared with 33% after a dummy treatment. They also needed fewer days of painkillers.1

7.6 → 2.8

average knee pain score out of 10, before and three months after a course of ozone injections, in a trial of 80 people with knee osteoarthritis.2

16 trials

A 2026 review of 1,172 patients found ozone injections reduced knee pain and improved movement compared with placebo, with the biggest benefit at around two months.3

Steroid-free

In head-to-head trials for shoulder and heel pain, ozone injections matched steroid injections at three months.45

How ozone injections work

Medical ozone is a precise mix of oxygen and a small amount of ozone (O3). Injected into or around painful tissue, it triggers a mild, controlled response in the body that is thought to calm inflammation, improve local oxygen and blood flow, and quieten pain signals.

On its own, an injection eases pain. Combined with physiotherapy, it gives you a window to rebuild strength and movement, so the problem is less likely to come back.

  • Calms inflammationOzone prompts the body's own antioxidant and anti-inflammatory defences in the treated area.
  • Boosts local oxygenIt improves blood flow and oxygen delivery to tissue that has stopped healing well.
  • Eases painLess inflammation means less pressure on nerves and less pain when you move.
  • Unlocks rehabWith pain down, your physiotherapist can progress the exercises that fix the cause.

Conditions we treat with ozone injections

Backed by clinical trials

  • Back and leg pain from a disc problem, including sciatica
  • Knee osteoarthritis
  • Shoulder pain and rotator cuff tendinopathy
  • Heel pain and plantar fasciitis

Also treated alongside physiotherapy

  • Neck pain
  • Hip, elbow, wrist and ankle pain
  • Achilles and other tendon problems
  • Ligament and muscle injuries
  • Slow-healing and long-standing injuries

Not sure if your problem is on the list? That's what the complimentary call is for.

What to expect

  1. Free suitability call

    Answer a few questions online, then one of our physiotherapists calls you back for up to 30 minutes to talk it through.

  2. Assessment and first injection

    A full assessment at the clinic, then your first injection if ozone is right for you. Allow up to an hour.

  3. Your course

    Sessions are usually every one to two weeks. Many of our patients feel a difference within three sessions.

  4. Rehab and boosters

    Physiotherapy builds on the results, with optional booster sessions to keep you moving.

Ozone results, in our patients' words

Read all reviews →
Arthritis in both feet · treated by Craig Hartley
“I’ve been in pain for 8 years!! … I’ve had ozone therapy in my feet and I’ll be honest I was pessimistic… I’ve just finished my last session with Craig, after 48 hours I got out of bed expecting the same as usual (pain), I was walking normal, no pain.”
David Evans · Google review, posted by Margaret Evans
Knees · Craig Hartley
“I have just completed a course of Ozone Therapy. I can now walk without pain, the stiffness has eased and I’m looking forward to a more mobile life in the future without surgery.”
Barbara Rooker · Google review
Back and neck · Peter Hartley
“In October I started a course of the Ozone therapy treatment for back pain and neck issues, I am really pleased with the results of my back treatment from which I’m now pain free.”
Julie Westlake · Google review
Knees and lower back · Peter Hartley
“He explained that if I carried on I would perhaps need replacements… I went ahead and now I'm walking with no pain in my knees and pelvis.”
Margaret Trott · Google review
Knee, pelvis and shoulder
“Now progressed to ozone injections in knee, pelvis and shoulder. After 3 appointments, what amazing results (it stings a bit 😂 but well worth it).”
Joanne Smith · Google review, about her husband

Safe hands, certified clinicians

Every ozone injection at Physio Barnsley is given by Peter Hartley or Craig Hartley, HCPC registered physiotherapists, certified medical ozone clinicians and trained phlebotomists.

  • Medical-grade ozoneProduced on site at precise, controlled concentrations.
  • Sterile, single-use equipmentFor every injection, every time.
  • A strong safety recordResearch reviews report no serious side effects. Minor reactions, such as short-lived soreness, affected about 4% of patients, similar to other injections.6
  • Suitability checked firstOn your complimentary call and again at your assessment.

Ozone injection questions

Anything else? Call us on 01226 391201 or book your complimentary suitability call.

What is Prolozone?

Prolozone is an injection of medical-grade oxygen-ozone into or around a painful joint, tendon, ligament or muscle. At Physio Barnsley it is always combined with physiotherapy.

Does the injection hurt?

Most people feel a brief sting and a feeling of pressure. The area can ache for a day or two afterwards, which is normal and settles on its own.

How is ozone different from a steroid injection?

Ozone contains no steroid. In trials for shoulder and heel pain, ozone matched steroid injections at three months. Steroids tend to work faster in the first few weeks, so we'll talk you through which suits you.

How many sessions will I need?

It depends on the problem and how long you've had it. Sessions are usually every one to two weeks, and we review your progress at every visit.

Is ozone injection safe?

Research reviews report no serious side effects from ozone injections, and minor reactions are uncommon. Your injection is given by a certified medical ozone clinician using sterile, single-use equipment.

Can ozone help me avoid surgery?

For some people, especially with disc-related back pain, ozone injections and physiotherapy relieve pain enough that surgery isn't needed. If we think surgery is the better route for you, we'll tell you.

Find out if ozone is right for you

Answer a few short questions, then choose a time for a complimentary 30 minute call with one of our physiotherapists.

References

  1. Paoloni M, et al. Intramuscular oxygen-ozone therapy in the treatment of acute back pain with lumbar disc herniation: a multicenter, randomized, double-blind, clinical trial of active and simulated lumbar paravertebral injection. Spine. 2009;34(13):1337–44. View study
  2. Hashemi M, et al. The effects of prolotherapy with hypertonic dextrose versus prolozone (intraarticular ozone) in patients with knee osteoarthritis. Anesthesiology and Pain Medicine. 2015;5(5):e27585. View study
  3. Chen F, et al. Ozone injection for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Frontiers in Pain Research. 2026. View study
  4. Atar MÖ, et al. Comparison of ultrasound-guided subacromial corticosteroid and ozone (O2-O3) injections in the treatment of chronic rotator cuff tendinopathy: a randomized clinical trial. Korean Journal of Pain. 2023;36(1):128–36. View study
  5. Bahrami MH, et al. Local ozone (O2-O3) versus corticosteroid injection efficacy in plantar fasciitis treatment: a double-blinded RCT. Journal of Pain Research. 2019;12:2251–9. View study
  6. Raeissadat SA, et al. An investigation into the efficacy of intra-articular ozone (O2-O3) injection in patients with knee osteoarthritis: a systematic review and meta-analysis. Journal of Pain Research. 2018;11:2537–50. View study

Results vary from person to person. Your physiotherapist will advise whether ozone is suitable for you.